Cachexia
MUSCLE WASTING IN HEART FAILURE
Patients with HF frequently report loss of muscle mass and strength, particularly in the arms and legs, that progresses as the HF syndrome becomes more advanced. It is thought that this skeletal muscle wasting contributes to the physical limitations experienced by patients with HF.
It has also been shown in a European cohort that patients with HF with greater muscle wasting have a shorter life-expectancy than those with preserved muscle mass. Our research team is seeking both methods to accurately and conveniently measure skeletal muscle mass and an understanding of the metabolic processes driving muscle wasting to enable us to develop new therapies to maintain muscle mass.
